West Melbourne is a suburb that lies 3 km north-west of Melbourne's Central Business District. West Melbourne is bounded by Victoria Street and the Sunbury/Werribee railway lines in the north, Footscray Road, the Moonee Ponds Creek and the Yarra River in the south. Peel Street and the Flagstaff Gardens help form the eastern boundary, with the western boundary defined by the Maribyrnong River and Coode Island.
Being largely an industrial area, a significant portion of West Melbourne is occupied by the Port of Melbourne, the Dynon Railway Yards and the Melbourne Markets. These include the Wholesale Fruit and Vegetable and Fish Markets, as well as the National Flower Centre.
It also contains a small pocket of residential and commercial properties, consisting of a mixture of Victorian single and double storey terrace houses and converted warehouses at the north-west corner of the Melbourne CBD. It is also adjacent to the Queen Victoria Market, located on corner of Victoria and Peel Streets.